MicroRNA Signatures of Breast Cancer | The Sample | GenomeWeb

Ohio State University's Carlo Croce and colleagues found a signature consisting of nine microRNAs that differentiate in situ and invasive ductal carcinoma in breast cancer. As they report in PNAS this week, the researchers examined the miRNA profiles of 80 invasive ductal carcinoma, eight ductal carcinoma in situ, and six normal breast biopsies. Though they note that the miRNA profiles of the breast to ductal carcinoma in situ transition and the in situ to invasive ductal carcinoma transition were largely similar, there were differences. "Specifically, let-7d, miR-210, and -221 were downregulated in the in situ and up-regulated in the invasive transition," the authors write. In addition, they found five miRNAs linked to overall survival or time to metastasis.

"MiR-210, which we showed here to be regulated during [breast cancer] progression, was also a component of the two prognostic signatures," the researchers report. "Finally, a set of highly prominent [breast cancer] genes was expressed in a miR-210 antagonistic fashion."

Source: http://www.genomeweb.com/blog/microrna-signatures-breast-cancer

the vow syracuse basketball new york knicks ke$ha earl csco lara logan